Good question but in her books Lanie has used the techniques on subjects that were awake. But let someone with more experience reply

I was reading about the Silva method -when you want to influence someone remotely - that works better at night when their brain and yours are in alpha as they will be receptive to your message. This worked for me in the past. (you just set your intention when you go to bed: 'I will wake up when my brain is connected to x, then you will wake up in the middle of the night when you are in alpha and they are open to your influence, and send your mental message with visualisation of the outcome then). Also the spells are indicated to be done during the time the target sleeps as they are also more vulnerable to mental influences because spells are actually intentions.